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Adam17tm1e(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Adam17tm1e(EUCOMM)Hmgu
Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4435244
Gene: Adam17  Location: Chr12:21373510-21423633 bp, - strand  Genetic Position: Chr12, 8.3 cM
IMPC: Adam17 gene page
Mutation
origin
Mutant Cell Lines:  HEPD0506_2_A02, HEPD0506_2_A03, HEPD0506_2_C01, HEPD0506_2_C02, HEPD0506_2_D02, HEPD0506_2_D03, HEPD0506_2_E01, HEPD0506_2_F03, HEPD0506_2_G02
Germline Transmission:  Unknown
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_st1
 
Mutation detailsThe L1L2_st1 cassette was inserted at position 21412212 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Adam17 Mutation:  62 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory