Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Terf1tm2.1Tdl
Name:	telomeric repeat binding factor 1; targeted mutation 2.1, Titia de Lange
MGI ID:	MGI:4431206
Synonyms:	TRF1F
Gene:	Terf1  Location: Chr1:15875870-15914276 bp, + strand  Genetic Position: Chr1, 4.88 cM, cytoband E3
Alliance:	Terf1tm2.1Tdl page

Germline Transmission:	Earliest citation of germline transmission: J:157331
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette leaving exon 1 floxed. (J:157331)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Terf1 Mutation:	35 strains or lines available

Original:	J:157331 Sfeir A, et al., Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 2009 Jul 10;138(1):90-103
All:	8 reference(s)