Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acacbtm1.1Dejs
Name:	acetyl-Coenzyme A carboxylase beta; targeted mutation 1.1, David James
MGI ID:	MGI:4430244
Synonyms:	ACC2 KO
Gene:	Acacb  Location: Chr5:114284748-114388822 bp, + strand  Genetic Position: Chr5, 55.97 cM
Alliance:	Acacbtm1.1Dejs page

Germline Transmission:	Earliest citation of germline transmission: J:157000
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon12 was flanked with loxP sites and a neomycin cassette was added. Cre-mediated recombination subsequently removed exon 12 and the neomycin selection cassette and caused a frameshift and an early stop codon. Mice were confirmed deficient by western blotting. (J:157000)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acacb Mutation:	109 strains or lines available

Original:	J:157000 Hoehn KL, et al., Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab. 2010 Jan;11(1):70-6
All:	5 reference(s)