Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ptgs2tm1.1Wls Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, William L Smith MGI ID: MGI:4420987 Synonyms: delta 18 muCox2 Gene: Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1 Alliance: Ptgs2tm1.1Wls page

Hypertoprhy of glomeruli in Ptgs2tm1Unc/Ptgs2tm1Unc mice that is not seen in Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:156331
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: Genomic sequence that codes for amino acids 595 through 612 was deleted by mutagenesis. A floxed neo cassette was inserted upstream of the modified exon 10. Cre mediated recombination removed the neo cassette. The predicted protein lacks the last 18 C-terminal amino acids. (J:156331)

Generation of the Ptgs2tm1.1Wls allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:156331 Wada M, et al., Two pathways for cyclooxygenase-2 protein degradation in vivo. J Biol Chem. 2009 Nov 6;284(45):30742-53
All:	1 reference(s)