Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-LRRK2)C7874Cai
Name:	transgene insertion C7874, Huaibin Cai
MGI ID:	MGI:4420758
Synonyms:	tetO-LRRK2
Transgene:	Tg(tetO-LRRK2)C7874Cai  Location: unknown
Alliance:	Tg(tetO-LRRK2)C7874Cai page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-LRRK2)C7874Cai expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human LRRK2 (120892) Lrrk2  (MGI:1913975)   Mutation details: A transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2 gene under the control of a tetO promoter. The construct was microinjected into C57BL/6J fertilized oocytes, and 5 independent lines were generated including line C7874. Founder mice were bred to C57BL/6J mice to establish this colony. (J:133490, J:154755, J:156512)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
All:	4 reference(s)