Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aars2tm1(KOMP)Wtsi
Name:	alanyl-tRNA synthetase 2, mitochondrial; targeted mutation 1, Wellcome Trust Sanger Institute
MGI ID:	MGI:4419134
Gene:	Aars2  Location: Chr17:45817767-45831769 bp, + strand  Genetic Position: Chr17, 22.51 cM
Alliance:	Aars2tm1(KOMP)Wtsi page
IMPC:	Aars2 gene page

Mutant Cell Lines:	EPD0406_3_A04, EPD0406_3_B03, EPD0406_3_C02, EPD0406_3_C04, EPD0406_3_D02, EPD0406_3_D03, EPD0406_3_D04, EPD0406_3_E01, EPD0406_3_E04, EPD0406_3_F03, EPD0406_3_F04, EPD0406_3_G02, EPD0406_3_G03, EPD0406_3_H01, EPD0406_3_H03
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 6330 starting at position 45819340 and ending at position 45825670 of Chromosome 17 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Aars2 Mutation:	41 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	4 reference(s)