Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp12tm1Rai
Name:	aquaporin 12; targeted mutation 1, Tatemitsu Rai
MGI ID:	MGI:4418194
Synonyms:	Aqp12tm1Suc
Gene:	Aqp12  Location: Chr1:92934056-92939991 bp, + strand  Genetic Position: Chr1, 46.72 cM
Alliance:	Aqp12tm1Rai page

Germline Transmission:	Earliest citation of germline transmission: J:155920
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a 1.8 kb neomycin cassette. Both Northern blot analysis an RT-PCR demonstrate the absence of transcript. (J:155920)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp12 Mutation:	20 strains or lines available

Original:	J:155920 Ohta E, et al., Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1368-78
All:	1 reference(s)