Gene Expression Data
Assay Details
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Assay
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Reference:
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J:153971
Giovannone B, et al., GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet. 2009 Dec 1;18(23):4629-39
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:4410290
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Gene symbol:
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Snca
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Gene name:
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synuclein, alpha
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Antibody:
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anti-a-synuclein
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Detection system:
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Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
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Results
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Specimen
5C:
postnatal month 15
(more  )
Specimen
5C:
(close  )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebellum granule cell layer |
Ambiguous |
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5C +/+
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Unlike in heterozygotes, expression is not present in coarse neurites. However, it may be present elsewhere in this structure.
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Specimen
5C:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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Specimen
5D--cortex:
postnatal month 15
(more )
Specimen
5D--cortex:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebral cortex |
Present |
Regionally restricted |
5D +/+ top
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Expression is present in neuritic plaques. Although there are none pictured in this image, based on the information is presented graphically in Fig. 5E, it appears that some are present in this structure.
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Specimen
5D--cortex:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebral cortex |
Present |
Regionally restricted |
5D +/- top
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Expression is present in neuritic plaques.
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Specimen
5D--midbrain:
postnatal month 15
(more )
Specimen
5D--midbrain:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: midbrain |
Present |
Regionally restricted |
5D +/+ bottom
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Expression is present in neuritic plaques. Although there are none pictured in this image, based on the information is presented graphically in Fig. 5E, it appears that there are some present in this structure.
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Specimen
5D--midbrain:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: midbrain |
Present |
Regionally restricted |
5D +/- bottom
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Expression is present in neuritic plaques. Their number is quantified in Fig. 5E.
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Specimen
cerebrum:
postnatal month 15
(more )
Specimen
cerebrum:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: telencephalon |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. There are fewer of them in wild type compared to heterozygotes. This information is presented graphically in Fig. 5E.
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Specimen
cerebrum:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: telencephalon |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. This information is presented graphically in Fig. 5E.
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Specimen
cerebellum:
postnatal month 15
(more )
Specimen
cerebellum:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebellum |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. This information is presented graphically in Fig. 5E.
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Specimen
cerebellum:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: cerebellum |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. This information is presented graphically in Fig. 5E.
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Specimen
spinal cord:
postnatal month 15
(more )
Specimen
spinal cord:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: spinal cord |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. There are fewer of them in wild type compared to heterozygotes. This information is presented graphically in Fig. 5E.
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Specimen
spinal cord:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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Gigyf2Gt(XH076)Byg/Gigyf2+
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Age:
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postnatal month 15
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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4% Paraformaldehyde
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Embedding:
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Paraffin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS28: spinal cord |
Present |
Regionally restricted |
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Expression is present in neuritic plaques. This information is presented graphically in Fig. 5E.
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Analysis Tools