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Ascl2tm2Nagy
Targeted Allele Detail
Summary
Symbol: Ascl2tm2Nagy
Name: achaete-scute family bHLH transcription factor 2; targeted mutation 2, Andras Nagy
MGI ID: MGI:4399141
Synonyms: Ascl2M2, M2
Gene: Ascl2  Location: Chr7:142520566-142523001 bp, - strand  Genetic Position: Chr7, 88.08 cM
Alliance: Ascl2tm2Nagy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153719
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette in which the coding sequence and polyadenylation site are flanked by loxP sites (PGK-loxP-neo-pA-loxP) was inserted 4.34 kb 3' of (centromeric to) the third, last coding exon of Ascl2, between Chr 7 imprinting center 1 (IC1/H19 DMR) and IC2/KvDMR1. (J:153719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ascl2 Mutation:  15 strains or lines available
References
Original:  J:153719 Lefebvre L, et al., The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Hum Mol Genet. 2009 Nov 15;18(22):4255-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory