Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camk2gtm1.1Irt
Name:	calcium/calmodulin-dependent protein kinase II gamma; targeted mutation 1.1, Ira Tabas
MGI ID:	MGI:4398829
Gene:	Camk2g  Location: Chr14:20784943-20844156 bp, - strand  Genetic Position: Chr14, 11.53 cM
Alliance:	Camk2gtm1.1Irt page

Germline Transmission:	Earliest citation of germline transmission: J:154647
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination removes exon 1 and 2. Exon 2 encodes part of the catalytic domain including the ATP binding motif essential for kinase function. The absence of protein expression was confirmed by western blot analysis of macrophage extracts. (J:154647)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camk2g Mutation:	35 strains or lines available

Original:	J:154647 Timmins JM, et al., Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest. 2009 Oct;119(10):2925-41
All:	14 reference(s)