Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tg(tetO-HTR4*D100A)7Niss Name: transgene insertion 7, Robert A Nissenson MGI ID: MGI:4367585 Synonyms: TetO-Rs1 Transgene: Tg(tetO-HTR4*D100A)7Niss  Location: unknown   Alliance: Tg(tetO-HTR4*D100A)7Niss page

Skeletal abnormalities in Tg(Col1a1-tTA)139Niss/0 Tg(tetO-HTR4*D100A)7Niss/0 mice Show the 5 phenotype image(s) involving this allele.

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Mutation details: The transgene vector was constructed to contain an aspartic acid to alanine amino acid residue change at position 100 making the gene product insensitive to serotonin. It is under the control of a TetO promoter. Three lines were established and designated as B (or 2), C, and G (or 7). This transgene was originally designated as line G (or 7). (J:131617)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:131617 Hsiao EC, et al., Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1209-14
All:	2 reference(s)