Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxc8tm2Jepl
Name:	homeobox C8; targeted mutation 2, Jeh-Ping Liu
MGI ID:	MGI:4365797
Synonyms:	Hoxc8F-LacZ
Gene:	Hoxc8  Location: Chr15:102899039-102902543 bp, + strand  Genetic Position: Chr15, 58.05 cM
Alliance:	Hoxc8tm2Jepl page

Germline Transmission:	Earliest citation of germline transmission: J:153560
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into exon 1 upstream of the initiation codon and a cassette containing a 5' loxP site, intron 2 sequence with flanking splice acceptor and donor sites, an IRES, a nuclear localized LacZ gene, an additional copy of the 3'UTR, and a neo resistance gene was inserted downstream of the 3'UTR. (J:153560)

Generation of the Hoxc8tm1Jepl and Hoxc8tm2Jepl alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc8 Mutation:	8 strains or lines available

Original:	J:153560 Blackburn J, et al., Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice. Genesis. 2009 Jul 20;47(10):680-687
All:	2 reference(s)