Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptpn11tm1.1Wbm
Name:	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1.1, Walter Birchmeier
MGI ID:	MGI:4365539
Synonyms:	Ptpn11tm1.1Cbm, Shp2fl
Gene:	Ptpn11  Location: Chr5:121268596-121329460 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Alliance:	Ptpn11tm1.1Wbm page

Germline Transmission:	Earliest citation of germline transmission: J:153219
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. The neo cassette was removed by germ line, flp mediated recombination. (J:153219)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:	43 strains or lines available

Original:	J:153219 Grossmann KS, et al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9
All:	10 reference(s)