Summary | Transgene origin | Transgene description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Trp53)1Srn
Name:	transgene insertion 1, Manuel Serrano
MGI ID:	MGI:4360913
Synonyms:	p53-tg, super p53
Transgene:	Tg(Trp53)1Srn  Location: unknown
Alliance:	Tg(Trp53)1Srn page

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Trp53)1Srn expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Trp53 (MGI:98834)   Mutation details: Bacterial artificial chromosome (BAC) library was used to obtain a 130 kb BAC containing the entire mouse Trp53 (transformation related protein 53) gene in it's "natural genomic context". Trp53 is located at the terminal end of the segment. The other end of the BAC falls in the middle of the Dnahc2 gene. This line carries one copy of the transgene.

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Trp53)1Srn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:80311 Garcia-Cao I, et al., 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 2002 Nov 15;21(22):6225-35
All:	15 reference(s)