Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Prnp-RTN3)2Yanr
Name:	transgene insertion 2, Riqiang Yan
MGI ID:	MGI:4359884
Synonyms:	hRTN3, RTN3-Tg2, Tg-RTN3, Tg-RTN3 line2
Transgene:	Tg(Prnp-RTN3)2Yanr  Location: unknown
Alliance:	Tg(Prnp-RTN3)2Yanr page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Prnp-RTN3)2Yanr expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human RTN3 (10313) Rtn3  (MGI:1339970)   Mutation details: The hRTN3 transgene was designed with a C-terminally myc-tagged human reticulon 3 (RTN3) cDNA inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at two unique XhoI sites in the Mo-Prp.Xho plasmid vector. This transgene was microinjected into the male pronuclei of fertilized FVB/N oocytes. Mice from founder line 2 (RTN3-Tg2) were bred with C57BL/6J mice to establish the colony. Line 2 expressed 1-2-fold higher levels of reticulon 3 compared to wild-type. (J:122560)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:122560 Hu X, et al., Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities. EMBO J. 2007 Jun 6;26(11):2755-67
All:	4 reference(s)