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Cyp51tm1Bfro
Targeted Allele Detail
Summary
Symbol: Cyp51tm1Bfro
Name: cytochrome P450, family 51; targeted mutation 1, Simon Horvat
MGI ID: MGI:4357830
Synonyms: Cyp51flox
Gene: Cyp51  Location: Chr5:4131145-4154746 bp, - strand  Genetic Position: Chr5, 2.3 cM, cytoband A2
Alliance: Cyp51tm1Bfro page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173366
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsHomology arms were isolated from BAC clone 519E21 (Research Genetics). An frt flanked PGKneo cassette was inserted in intron 3 and loxP sites were inserted in introns 2 and 4. The neo selection cassette was removed from correctly targeted ES cells by Flp mediated recombinase. (J:173366)
Generation of the Cyp51tm1Bfro and Cyp51tm1.1Bfro alleles
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp51 Mutation:  24 strains or lines available
References
Original:  J:173366 Keber R, et al., Mouse knockout of the cholesterogenic cytochrome P450 lanosterol 14alpha-demethylase (Cyp51) resembles Antley-Bixler syndrome. J Biol Chem. 2011 Aug 19;286(33):29086-97
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory