Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Ifnb1tm1Lky
Name:	interferon beta 1, fibroblast; targeted mutation 1, Richard M Locksley
MGI ID:	MGI:4357661
Synonyms:	Ifnb1tm1(EYFP)Lky, Ifnbmob, mob
Gene:	Ifnb1  Location: Chr4:88440262-88441011 bp, - strand  Genetic Position: Chr4, 41.91 cM
Alliance:	Ifnb1tm1Lky page

Germline Transmission:	Earliest citation of germline transmission: J:152138
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A bicistronic reporter cassette containing a loxP-flanked neomycin cassette, an encephalomyocarditis virus (EMCV) IRES element, and enhanced yellow fluorescent protein (EYFP) was introduced immediately after the Ifnb1 STOP codon. The use of 129 background embryonic stem (ES) cells expressing cre under the control of the germline-specific protamine (Prm) promoter allowed for the cre-mediated excision of the floxed neomycin gene from the male germline. The line was backcrossed to C57BL/6 to breed cre out of the line. (J:152138)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifnb1 Mutation:	20 strains or lines available

Original:	J:152138 Scheu S, et al., Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20416-21
All:	28 reference(s)