Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Apoe-Fgf21)1Sakl
Name:	transgene insertion 1, Steven A Kliewer
MGI ID:	MGI:4354167
Synonyms:	Tg(Fgf21)
Transgene:	Tg(Apoe-Fgf21)1Sakl  Location: unknown
Alliance:	Tg(Apoe-Fgf21)1Sakl page

Strain of Origin:

C57BL/6NCrl

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Apoe-Fgf21)1Sakl expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Fgf21 (MGI:1861377)   Mutation details: The mouse promoter was used to drive liver-specific expression of the mouse cDNA. Two lines were created (1 and 2) that result in 50-fold, and 150-fold, respectively, higher expression of the transcript compared to in wild-type mice. The two lines exhibit virtually identical changes in fasting serum beta-hydroxybutyrate, triglyceride, total cholesterol, glucose, and insulin concentrations. Line 1 was selected as the representative line. (J:129855)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:129855 Inagaki T, et al., Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21. Cell Metab. 2007 Jun;5(6):415-25
All:	18 reference(s)