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Il2m1
Spontaneous Allele Detail
Summary
Symbol: Il2m1
Name: interleukin 2; mutation 1
MGI ID: MGI:4352594
Gene: Il2  Location: Chr3:37174862-37180103 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Alliance: Il2m1 page
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous
Mutation:    Undefined
 
Mutation detailsThis hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. (J:75331)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:  41 strains or lines available
References
Original:  J:75331 Choi Y, et al., Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol. 2002 Mar;32(3):677-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory