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Tg(MMTV-rtTA)4-1Jek
Transgene Detail
Summary
Symbol: Tg(MMTV-rtTA)4-1Jek
Name: transgene insertion 4-1, Jeffrey E Kudlow
MGI ID: MGI:3850385
Synonyms: MMTV-rtTA, MMTV-rtTA-SV40
Transgene: Tg(MMTV-rtTA)4-1Jek  Location: unknown  
Alliance: Tg(MMTV-rtTA)4-1Jek page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThe MMTV-rtTA-SV40 transgene was designed with the 1.5 kb mouse mammary tumor virus long terminal repeat (MMTV-LTR) promoter, the reverse tetracycline transactivator gene and VP16 activation domain (rtTA-VP16), and SV40 intron/polyA sequence. The rtTA-VP16-polyA sequence is inserted into exon 3 of the rabbit beta-globin gene immediately following the MMTV promoter. This 3.75 kb transgene was injected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder line 4-1 were bred with C57BL/6;SJL wildtype mice to establish the colony. (J:134284)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:134284 Whisenhunt TR, et al., Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development. Glycobiology. 2006 Jun;16(6):551-63
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory