Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slfn2m1Btlr
Name:	schlafen 2; mutation 1, Bruce Beutler
MGI ID:	MGI:3850348
Synonyms:	elektra, Slfn2eka
Gene:	Slfn2  Location: Chr11:82955938-82961504 bp, + strand  Genetic Position: Chr11, 50.3 cM
Alliance:	Slfn2m1Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: This mutation comprises a T to A transversion at nucleotide position 586 of the gene (Genbank Accession NM_011408) that results in replacement of isoleucine by asparagine at amino acid position 135 of the protein (I135N). (J:158985) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slfn2 Mutation:	13 strains or lines available

Original:	J:158985 Berger M, et al., An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol. 2010 Apr;11(4):335-43
All:	4 reference(s)