Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dicer1tm1.1Mnn
Name:	dicer 1, ribonuclease type III; targeted mutation 1.1, Jeff Mann
MGI ID:	MGI:3850191
Synonyms:	Dicer1c
Gene:	Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance:	Dicer1tm1.1Mnn page

Germline Transmission:	Earliest citation of germline transmission: J:150221
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 25 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 27. Germ line, flp mediated recombination removed the neo cassette leaving exons 25 through 27 floxed. (J:150221)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:	94 strains or lines available

Original:	J:150221 Mattiske DM, et al., Meiotic maturation failure induced by DICER1 deficiency is derived from primary oocyte ooplasm. Reproduction. 2009 Apr;137(4):625-32
All:	3 reference(s)