Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Angptl3tm1Lex
Name:	angiopoietin-like 3; targeted mutation 1, Lexicon Pharmaceuticals
MGI ID:	MGI:3849576
Synonyms:	Angptl3-
Gene:	Angptl3  Location: Chr4:98919191-98926429 bp, + strand  Genetic Position: Chr4, 45.6 cM
Alliance:	Angptl3tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:149912
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The first 4 exons of the gene were replaced with a lacZ/neomycin cassette. Correct targeting was confirmed by Southern blotting. (J:149912)

Generation of the Angptl3tm1Lex allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Angptl3 Mutation:	35 strains or lines available

Original:	J:149912 Lee EC, et al., Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem. 2009 May 15;284(20):13735-45
All:	7 reference(s)