Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fmn1tm2Made
Name:	formin 1; targeted mutation 2, Markus Dettenhofer
MGI ID:	MGI:3848983
Synonyms:	Fmn1Pro
Gene:	Fmn1  Location: Chr2:113158081-113547112 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Alliance:	Fmn1tm2Made page

Germline Transmission:	Earliest citation of germline transmission: J:149484
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 9. This insertion leads to a disruption at the proline-rich FH1 domain. The absence of protein was confirmed by western blot analysis of embryonic fibroblasts extracts. (J:149484)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:	75 strains or lines available

Original:	J:149484 Zhou F, et al., Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 1;18(13):2472-82
All:	1 reference(s)