Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(SMN2*A111G)591Ahmb
Name:	transgene insertion 591, Arthur H M Burghes
MGI ID:	MGI:3847326
Synonyms:	A591, line 591, SMN(A111G), SMN(A11G)
Transgene:	Tg(SMN2*A111G)591Ahmb  Location: unknown
Alliance:	Tg(SMN2*A111G)591Ahmb page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(SMN2*A111G)591Ahmb expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SMN2 (6607) Smn1  (MGI:109257)   Mutation details: : A transgenic construct containing the SMN(A111G) missense mutation under the control of 4.1 kb SMN promoter was injected into fertilized FVB/N mouse eggs. Ten founder lines were obtained and line 588 was subsequently established. This line was found to have 5 copies of the transgene. (J:148541)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:148541 Workman E, et al., A SMN missense mutation complements SMN2 restoring snRNPs and rescuing SMA mice. Hum Mol Genet. 2009 Jun 15;18(12):2215-29
All:	1 reference(s)