Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: RhoTvrm4 Name: rhodopsin; translational research vision model 4 MGI ID: MGI:3845397 Synonyms: I307N Rho Gene: Rho  Location: Chr6:115908709-115916997 bp, + strand  Genetic Position: Chr6, 53.72 cM Alliance: RhoTvrm4 page

Light-induced degeneration of photoreceptors in RhoTvrm4/Rho+ mice Show the 3 phenotype image(s) involving this allele.

Strain of Origin:

(129S4/SvJae x C57BL/6J)F1

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: A missense mutation changes amino acid 307, isoleucine (ATC), to asparagine (AAC). Ile-307 is located in the 7th transmembrane region of RHO and is conserved across species, including human, primate, cat, dog, and rat. (J:159523) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rho Mutation:	48 strains or lines available

Original:	J:159523 Budzynski E, et al., Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 7;285(19):14521-33
All:	7 reference(s)