Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Dclk2tm1.2Jgg Name: doublecortin-like kinase 2; targeted mutation 1.2, Joseph G Gleeson MGI ID: MGI:3844726 Gene: Dclk2  Location: Chr3:86693458-86828159 bp, - strand  Genetic Position: Chr3, 37.88 cM Alliance: Dclk2tm1.2Jgg page

Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:148345
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neomycin selection cassette was inserted downstream of the exon. Exon 2 was removed by crossing founder mice with transgenic mice that express cre recombinase in the germline removed exon 2, and led to an out-of-frame mutation and the appearance of a stop codon within exon 3. Immunoblot analysis indicated a reduction in protein expression in heterozygote brain, and absence of protein in homozygote brain. (J:148345)

Generation of the Dclk2tm1Jgg and Dclk2tm1.2Jgg alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dclk2 Mutation:	134 strains or lines available

Original:	J:148345 Kerjan G, et al., Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71
All:	1 reference(s)