Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Camk2a-UBB*)3413-1Fwvl
Name:	transgene insertion 3413-1, FW van Leeuwen
MGI ID:	MGI:3843483
Synonyms:	UBB+1 3413, UBB+1 3413
Transgene:	Tg(Camk2a-UBB*)3413-1Fwvl  Location: unknown
Alliance:	Tg(Camk2a-UBB*)3413-1Fwvl page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Camk2a-UBB*)3413-1Fwvl expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human UBB (7314) Ubb  (MGI:98888)   Mutation details: A transgenic construct containing cDNA encoding the mutant human ubiquitin B, UBB+1 sequence (in the +1 reading frame), under the direction of the mouse Camk2a (calcium/calmodulin-dependent protein kinase II alpha) promoter was injected into fertilized C57BL/6 mouse eggs. Founder line 3413-1 with 13 copies of the transgene was subsequently established. mRNA levels for UBB+1 are 49% of endogenous Ubb mRNA levels. (J:147938)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:147938 Fischer DF, et al., Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiol Aging. 2009 Jun;30(6):847-63
All:	7 reference(s)