Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Ckm-IGF1R*K1003R)1Dlr
Name:	transgene marker 1, Derek LeRoith
MGI ID:	MGI:3842765
Synonyms:	MCK-KR-hIGF-IR, MKR
Transgene:	Tg(Ckm-IGF1R*K1003R)1Dlr  Location: unknown
Alliance:	Tg(Ckm-IGF1R*K1003R)1Dlr page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Ckm-IGF1R*K1003R)1Dlr expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human IGF1R (3480) Igf1r  (MGI:96433)   Mutation details: The promoter, enhancer 1, exon 1, first intron/enchancer 2, and first 16 base pairs of exon 2 were used to drive muscle-specific expression of a dominant-negative human gene with nucleotide substitutions that result in the amino acid substitution of arginine for lysine at position 1003 (K1003R). Five lines were created with around 12 copies of the transgene. No line names were given. (J:71205)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:71205 Fernandez AM, et al., Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev. 2001 Aug 1;15(15):1926-34
All:	35 reference(s)