Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Abcb1atm1.1Kane
Name:	ATP-binding cassette, sub-family B member 1A; targeted mutation 1.1, Susan E Kane
MGI ID:	MGI:3842697
Synonyms:	Mdr1aFluc
Gene:	Abcb1a  Location: Chr5:8710077-8798575 bp, + strand  Genetic Position: Chr5, 3.43 cM
Alliance:	Abcb1atm1.1Kane page

Germline Transmission:	Earliest citation of germline transmission: J:147139
Parent Cell Line:	2A (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Intragenic deletion   Mutation details: Mice carrying the Abcb1atm1Kane allele were crossed with the Hprttm1(cre)Mnn allele to remove exon 2 and the neomycin resistance cassette from the germline. Luciferase expression was detected in the intestinal tract, the liver, kidney and spleen of heterozygote mice. (J:147139)

Generation of the Abcb1atm1Kane and Abcb1atm1.1Kane alleles

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcb1a Mutation:	93 strains or lines available

Original:	J:147139 Gu L, et al., A new model for studying tissue-specific mdr1a gene expression in vivo by live imaging. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5394-9
All:	2 reference(s)