Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Achetm4Pata
Name:	acetylcholinesterase; targeted mutation 4, Palmer Taylor
MGI ID:	MGI:3842444
Synonyms:	AChE del E5+6-, AChEdel E5 + 6/Neo
Gene:	Ache  Location: Chr5:137286516-137292728 bp, + strand  Genetic Position: Chr5, 76.32 cM
Alliance:	Achetm4Pata page

Germline Transmission:	Earliest citation of germline transmission: J:147855
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 5 and 6 were replaced with a floxed neo cassette. Ache serum activity is dramatically reduced compared to in wild-type mice. (J:147855)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ache Mutation:	30 strains or lines available

Original:	J:147855 Camp S, et al., Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion. Chem Biol Interact. 2005 Dec 15;157-158:79-86
All:	4 reference(s)