Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyp11b2tm2Hsk
Name:	cytochrome P450, family 11, subfamily b, polypeptide 2; targeted mutation 2, Hyung-Suk Kim
MGI ID:	MGI:3842189
Synonyms:	AShi, Cyp11b2tm2Unc
Gene:	Cyp11b2  Location: Chr15:74722859-74728167 bp, - strand  Genetic Position: Chr15, 34.29 cM
Alliance:	Cyp11b2tm2Hsk page

Germline Transmission:	Earliest citation of germline transmission: J:147672
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The non-coding region of exon 9 was replaced with duplicate copies of the bovine growth hormone 3'UTR with its GU/U rich element and a floxed neo cassette. Transcript expression in homozygotes is increased 150% compared to in wild-type mice, as determined by RT-PCR. (J:147672)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp11b2 Mutation:	40 strains or lines available

Original:	J:147672 Makhanova N, et al., Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension. 2008 Jan;51(1):134-40
All:	1 reference(s)