Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Axin1tm4Cos
Name:	axin 1; targeted mutation 4, Frank Costantini
MGI ID:	MGI:3840238
Synonyms:	AxindeltaC6
Gene:	Axin1  Location: Chr17:26357662-26414785 bp, + strand  Genetic Position: Chr17, 13.07 cM
Alliance:	Axin1tm4Cos page

Germline Transmission:	Earliest citation of germline transmission: J:147293
Parent Cell Line:	CSL3 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: Exon 2 was replaced with a myc-tagged cDNA lacking the six C-terminal amino acids followed by a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. Western blot confirmed that protein expression was reduced 3- to 4-fold compared to in wild-type mice. (J:147293)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Axin1 Mutation:	44 strains or lines available

Original:	J:147293 Chia IV, et al., Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis. Genetics. 2009 Apr;181(4):1359-68
All:	2 reference(s)