Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Heg1tm1Mlkn
Name:	heart development protein with EGF-like domains 1; targeted mutation 1, Mark L Kahn
MGI ID:	MGI:3838392
Gene:	Heg1  Location: Chr16:33504754-33591946 bp, + strand  Genetic Position: Chr16, 24.17 cM
Alliance:	Heg1tm1Mlkn page

Germline Transmission:	Earliest citation of germline transmission: J:146528
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a LacZ gene and neo cassette via homologous recombination. RT-PCR confirmed the absence of RNA expression in homozygous embryos. (J:146528)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Heg1 Mutation:	56 strains or lines available

Original:	J:146528 Kleaveland B, et al., Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb;15(2):169-76
All:	2 reference(s)