Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mark3tm1Hpw
Name:	MAP/microtubule affinity regulating kinase 3; targeted mutation 1, Helen Piwnica-Worms
MGI ID:	MGI:3836595
Synonyms:	cTak KO, Par-1a-
Gene:	Mark3  Location: Chr12:111540957-111622655 bp, + strand  Genetic Position: Chr12, 61.05 cM, cytoband F2
Alliance:	Mark3tm1Hpw page

Germline Transmission:	Earliest citation of germline transmission: J:163905
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A 1.9 kb fragment of the gene was disrupted by the insertion of a neomycin resistance cassette. Exon 2 (hosting the ATP binding site) and the 5' slice site of intron 2/3 were shifted out of frame. Multi-tissue Western blotting confirmed ablation of this gene in all tissues of homozygous null-mice.

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mark3 Mutation:	71 strains or lines available

Original:	J:163905 Lennerz JK, et al., Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol. 2010 Nov;30(21):5043-56
All:	1 reference(s)