Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptpn5tm1Pjlo
Name:	protein tyrosine phosphatase, non-receptor type 5; targeted mutation 1, Paul J Lombroso
MGI ID:	MGI:3835526
Synonyms:	STEP-
Gene:	Ptpn5  Location: Chr7:46727543-46783432 bp, - strand  Genetic Position: Chr7, 30.7 cM, cytoband B3-B5
Alliance:	Ptpn5tm1Pjlo page

Germline Transmission:	Earliest citation of germline transmission: J:145584
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1284 bp of genomic sequence encoding the catalytic site was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145584)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn5 Mutation:	28 strains or lines available

Original:	J:145584 Venkitaramani DV, et al., Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse. 2009 Jan;63(1):69-81
All:	21 reference(s)