Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Draxintm1Htnk
Name:	dorsal inhibitory axon guidance protein; targeted mutation 1, Hideaki Tanaka
MGI ID:	MGI:3833678
Synonyms:	Draxin-
Gene:	Draxin  Location: Chr4:148182894-148215155 bp, - strand  Genetic Position: Chr4, 78.67 cM, cytoband E1
Alliance:	Draxintm1Htnk page

Germline Transmission:	Earliest citation of germline transmission: J:144923
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A LacZ cassette and a floxed neomycin cassette replaced exon 2 downstream of the ATG start site. Gene inactivation was confirmed in homozygotes by a lack of protein detected by immunohistochemistry on traverse sections of E10.5 spinal cord. LacZ expression was detected in heterozygote embryonic brains. (J:144923)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Draxin Mutation:	16 strains or lines available

Original:	J:144923 Islam SM, et al., Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science. 2009 Jan 16;323(5912):388-93
All:	10 reference(s)