Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trafd1tm1Ayos
Name:	TRAF type zinc finger domain containing 1; targeted mutation 1, Akihiko Yoshimura
MGI ID:	MGI:3831676
Synonyms:	FLN29-
Gene:	Trafd1  Location: Chr5:121509788-121523695 bp, - strand  Genetic Position: Chr5, 61.78 cM
Alliance:	Trafd1tm1Ayos page

Germline Transmission:	Earliest citation of germline transmission: J:144594
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:144594)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trafd1 Mutation:	29 strains or lines available

Original:	J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
All:	1 reference(s)