Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Traf3ip2tm1Sbn
Name:	TRAF3 interacting protein 2; targeted mutation 1, Ulrich Siebenlist
MGI ID:	MGI:3831153
Synonyms:	CIKS-
Gene:	Traf3ip2  Location: Chr10:39488930-39531303 bp, + strand  Genetic Position: Chr10, 20.86 cM
Alliance:	Traf3ip2tm1Sbn page

Germline Transmission:	Earliest citation of germline transmission: J:144320
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.6 Kb BamHI fragment containing exon 2 was replaced with a neomycin selection cassette. Correct targeting was confirmed by Southern blotting. Analysis of mRNAs from homozygote B cells demonstrates exon 1 was spliced to exon 3. All potential ATG start codons upstream of exon 3 and located in the correct reading frame are followed by at least 2 stop codons prior to the start of exon 3. The first ATG present within the functional reading frame downstream of the start of exon 3 is located in exon 5, which could only generate a 157 amino acid long fragment of the 555 amino acid endogenous protein. For these reasons, a functional protein product was considered unlikely. (J:144320)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf3ip2 Mutation:	41 strains or lines available

Original:	J:144320 Claudio E, et al., The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol. 2009 Feb 1;182(3):1617-30
All:	14 reference(s)