Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl2tm1Irt
Name:	B cell leukemia/lymphoma 2; targeted mutation 1, Ira Tabas
MGI ID:	MGI:3830735
Synonyms:	Bcl2flox, Bcl2-flox
Gene:	Bcl2  Location: Chr1:106465908-106642004 bp, - strand  Genetic Position: Chr1, 49.76 cM
Alliance:	Bcl2tm1Irt page

Germline Transmission:	Earliest citation of germline transmission: J:144243
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to place a loxP-flanked neo cassette upstream of exon 2, as well as a loxP site downstream of exon 2 of the targeted gene. (J:144243)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2 Mutation:	41 strains or lines available

Original:	J:144243 Thorp E, et al., Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2. Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):169-72
All:	7 reference(s)