Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnq3tm1Dgen
Name:	potassium voltage-gated channel, subfamily Q, member 3; targeted mutation 1, Deltagen
MGI ID:	MGI:3830636
Gene:	Kcnq3  Location: Chr15:65858236-66158491 bp, - strand  Genetic Position: Chr15, 29.16 cM
Alliance:	Kcnq3tm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:142688
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Bases 1803 to 1824 were replaced with a lacZ/neo cassette. The absence of protein expression was confirmed by the failure to generate outward current by application of retigabine to hippocampal slices. (J:142688)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq3 Mutation:	48 strains or lines available

Original:	J:142688 Tzingounis AV, et al., Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19974-9
All:	1 reference(s)