Twsg1tm1.1Mboc
Targeted Allele Detail
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Symbol: |
Twsg1tm1.1Mboc |
Name: |
twisted gastrulation BMP signaling modulator 1; targeted mutation 1.1, Michael B O'Connor |
MGI ID: |
MGI:3830633 |
Synonyms: |
Twsg1- |
Gene: |
Twsg1 Location: Chr17:66230060-66258198 bp, - strand Genetic Position: Chr17, 35.26 cM
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Alliance: |
Twsg1tm1.1Mboc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:88784
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An Frt flanked PGK-neomycin cassette with a 3' loxP site was inserted in intron 2. A second loxP site was inserted 3' to exon 3. These mice were crossed to mice carrying Tg(ACTB-cre)2Mrt in order to excise exon 3. Mice resulting from this cross express a truncated message. Presence or absence of the PGK neo cassette has no affect on phenotype.
(J:88784)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Twsg1 Mutation: |
20 strains or lines available
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Original: |
J:88784 Petryk A, et al., The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev Biol. 2004 Mar 15;267(2):374-86 |
All: |
7 reference(s) |
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