Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Inpp5dtm1Wgk
Name:	inositol polyphosphate-5-phosphatase D; targeted mutation 1, William G Kerr
MGI ID:	MGI:3830362
Synonyms:	SHIPflox
Gene:	Inpp5d  Location: Chr1:87548034-87648229 bp, + strand  Genetic Position: Chr1, 44.44 cM, cytoband C5
Alliance:	Inpp5dtm1Wgk page

Germline Transmission:	Earliest citation of germline transmission: J:95215
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neomycin cassette was placed downstream of exon 1. Cre recombinase was transiently expressed in correctly targeted ES cells to remove the neomycin selection cassette, leaving exon 1 flanked by loxP sites. Genomic PCR and Southern blotting confirmed removal of the neo cassette and the flox-state of exon 1. (J:95215, J:144110)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Inpp5d Mutation:	93 strains or lines available

Original:	J:95215 Wang JW, et al., Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science. 2002 Mar 15;295(5562):2094-7
All:	20 reference(s)