Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis
Transgene Detail
|
|
| Symbol: |
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis |
| Name: |
transgene insertion 1, Yuji Mishina |
| MGI ID: |
MGI:3829221 |
| Synonyms: |
caBmpr1a |
| Transgene: |
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis Location: unknown
|
| Alliance: |
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:143588
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
129S7/SvEvBrd-Hprt1b-m2
|
|
| Transgene Type: |
|
Transgenic (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence, Reporter) |
| Mutation: |
|
Insertion
|
| |
|
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
BMPR1A (657) |
|
|
|
| |
|
Mutation details: The modified chicken beta-actin promoter (CAG) was used to drive ubiquitous expression of a floxed lacZ gene with a nuclear localization signal and a triple polyadenylation sequence. The floxed cassette is followed by a constitutively active human BMPR1A sequence with the amino acid substitution of aspartic acid for glutamine at position 227 (Q227D), an IRES sequence, and the EGFP coding sequence. Expression of the constitutively active BMPR1A and EGFP are cre-dependent. No line information is available.
(J:143588)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
| Original: |
J:143588 Kamiya N, et al., BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11 |
| All: |
9 reference(s) |
|
Analysis Tools
