Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pcdhatm5Tyag
Name:	protocadherin alpha cluster; targeted mutation 5, Takeshi Yagi
MGI ID:	MGI:3829039
Synonyms:	PcdhalphadeltaAneo
Gene:	Pcdha  Location: unknown  Genetic Position: Chr18, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:143248
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: An in-frame termination codon was inserted just after the A and B common region in the constant region third exon along with a floxed neomycin resistance gene cassette. The absence of full-length isoform A protein expression was confirmed by western blot analysis on brain extracts. (J:143248)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pcdha Mutation:	52 strains or lines available

Original:	J:143248 Fukuda E, et al., Down-regulation of protocadherin-alpha A isoforms in mice changes contextual fear conditioning and spatial working memory. Eur J Neurosci. 2008 Oct;28(7):1362-76
All:	2 reference(s)