Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Gt(ROSA)26Sortm3(Gli3)Amc
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Andrew P McMahon
MGI ID:	MGI:3828280
Synonyms:	Gli3TFlagc, R26-Gli3T, RosaGli3TFlag
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm3(Gli3)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:143454
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129 and C57BL/6 and CBA and Swiss Webster

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm3(Gli3)Amc expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Gli3 (MGI:95729)   Mutation details: A loxP site flanked neomycin resistance gene cassette, a cDNA encoding the first 740 amino acids of Gli3, three copies of the sequence coding for a flag tag, and an IRES-YFP (Venus) cassette were inserted into the locus. Expression is only achieved following cre-mediated removal of the floxed neo cassette. (J:143454)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:143454 Vokes SA, et al., A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 2008 Oct 1;22(19):2651-63
All:	13 reference(s)