Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arg1tm1.1Pmu
Name:	arginase, liver; targeted mutation 1.1, Peter J Murray
MGI ID:	MGI:3826848
Synonyms:	Arg1delta
Gene:	Arg1  Location: Chr10:24791105-24803368 bp, - strand  Genetic Position: Chr10, 12.26 cM
Alliance:	Arg1tm1.1Pmu page

Germline Transmission:	Earliest citation of germline transmission: J:143229
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Mice carrying the floxed allele Arg1tm1Pmu were crossed with a transgenic cre recombinase mouse strain to remove exons 7 and 8 from germline cells. Gene inactivation was confirmed by genomic PCR. This is a null allele. (J:143229)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arg1 Mutation:	25 strains or lines available

Original:	J:143229 El Kasmi KC, et al., Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008 Dec;9(12):1399-406
All:	4 reference(s)