Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Tcra,Tcrb)9Rest
Name:	transgene insertion 9, Nicholas P Restifo
MGI ID:	MGI:3826818
Synonyms:	TRP-1 TCR
Transgene:	Tg(Tcra,Tcrb)9Rest  Location: unknown  Genetic Position: ChrY, Syntenic
Alliance:	Tg(Tcra,Tcrb)9Rest page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Tcra,Tcrb)9Rest expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Tcra (MGI:98553) mouse Tcrb (MGI:98578)   Mutation details: The TRP-1 TCR was generated from immunized Tyrp1B-w mice. Clone 7A6 expressed Valpha3.2Vbeta14 TCR chains. These TCR sequences were cloned into separate vectors and co-injected into microinjected into C57BL/6 fertilized eggs. Founder line 9 was subsequently established and the transgene insertion site was found on the Y chromosome. (J:138466)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:138466 Muranski P, et al., Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008 Jul 15;112(2):362-73
All:	27 reference(s)