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Senp1Gt(XG001)Byg
Gene trapped Allele Detail
Summary
Symbol: Senp1Gt(XG001)Byg
Name: SUMO1/sentrin specific peptidase 1; gene trap XG001, BayGenomics
MGI ID: MGI:3818522
Gene: Senp1  Location: Chr15:97936625-97991625 bp, - strand  Genetic Position: Chr15, 54.04 cM
Alliance: Senp1Gt(XG001)Byg page
Mutation
origin
Mutant Cell Line:  XG001
Germline Transmission:  Earliest citation of germline transmission: J:141453
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation details: A gene trap vector pGT1Lxf, which contains a beta-geo cassette, was inserted into intron 8. The presence of a truncated transcript was confirmed by RT-PCR. (J:141453)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Senp1 Mutation:  65 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:141453 Cheng J, et al., SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory