Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tdp1Gt(XD105)Byg
Name:	tyrosyl-DNA phosphodiesterase 1; gene trap XD105, BayGenomics
MGI ID:	MGI:3818340
Gene:	Tdp1  Location: Chr12:99850776-99921478 bp, + strand  Genetic Position: Chr12, Syntenic
Alliance:	Tdp1Gt(XD105)Byg page

Mutant Cell Line:	XD105
Germline Transmission:	Earliest citation of germline transmission: J:127602
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap   Mutation details: A gene trap vector containing a beta-geo cassette was inserted downstream of exon 10. The absence of protein expression was confirmed by western blot analysis on cortex, cerbellum and spleen extracts. (J:127605) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select XD105 CC178359 (MGI Seq Detail) 5' RACE Chr12:99872353-99878580 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 4 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tdp1 Mutation:	53 strains or lines available

Original:	J:127605 Katyal S, et al., TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J. 2007 Nov 14;26(22):4720-31
All:	11 reference(s)